The Vikings have won 15 of their last 20 games against the Cardinals and 11 in a row at home, most recently in 2022. The last time they lost to this franchise in Minnesota, the year was 1977 and the Cardinals were located in St. Louis. Kevin O'Connell's team will look to keep that streak alive today.

The Vikings are favored by 3.5 points in the latest Vikings vs. Cardinals odds, while the over/under is 45 points per SportsLine consensus. Minnesota is a -172 money line favorite (risk $172 to win $100),

Jordan Addison scored a touchdown in Week 1 last year for Vikings fans. This year, we saw Xavier Worthy score two touchdowns on opening night. Rookies impact the league every year, and the Vikings need to keep hitting on their first-round picks. Kwesi Adofo-Mensah had a rough first two rounds in 2022, but 2023 and 2024 have looked good thus far.