Buffalo Bills wide receiver Mack Hollins, middle left, scores a touchdown past San Francisco 49ers cornerback Charvarius Ward ...

Josh Allen scored a receiving touchdown on a pass he threw in his latest do-everything performance, and the Buffalo Bills ...

Buffalo has run consistently over the previously perceived vaunted 49ers defense to jump up to a halftime lead.

Buffalo Bills wide receiver Amari Cooper became the 62nd player in NFL history with 700 receptions in about the oddest way ...

Josh Allen’s latest kneel-down had nothing to do with football. The Buffalo Bills quarterback and actor Hailee Steinfeld posted a photo to their Instagram followers on Friday — 20.3 million for ...

The 49ers have been struggling for much of the season, but they had no shot in the snow on Sunday night in Western New ...

Post-Thanksgiving travel was treacherous in parts of the Great Lakes region Sunday due to several feet of lake-effect snow, ...

The 49ers' third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at ...

The San Francisco 49ers' losses to the Green Bay Packers and Buffalo Bills mark the worst two-game stretch by a defending ...

The 49ers just lost 35-10 to the Buffalo Bills. Now the 49ers are 5-7 and all alone in last place in the NFL West. Here are ...

ORCHARD PARK, N.Y. (WROC) — In wintry conditions at Highmark Stadium, the Bills took down the 49ers 35-10 to win their fifth ...

San Francisco 49ers running back Christian McCaffrey suffered a knee injury and limped to the locker room in the second ...