The San Francisco 49ers' losses to the Green Bay Packers and Buffalo Bills mark the worst two-game stretch by a defending ...

The 49ers just lost 35-10 to the Buffalo Bills. Now the 49ers are 5-7 and all alone in last place in the NFL West. Here are ...

The San Francisco 49ers suffered another crushing defeat Sunday night, falling 35-10 to the Buffalo Bills. The loss marked ...

Josh Allen scored a receiving touchdown on a pass he threw in his latest do-everything performance, and the Buffalo Bills ...

San Francisco 49ers quarterback Brock Purdy is poised to return to action on Sunday night against the Buffalo Bills after ...

San Francisco 49ers star running back Christian McCaffrey departed Sunday night's snow game against the Buffalo Bills early ...

Before the 2024 NFL season, Sunday night's Week 13 matchup between the Buffalo Bills and San Francisco 49ers might've been ...

Buffalo Bills outside linebacker Greg Rousseau chases down San Francisco 49ers quarterback Brock Purdy to boosts his 2024 NFL ...

Brandon Allen is 2-8 in 10 career starts. One of them was against Josh Allen and the Bills but Brandon Allen wore No. 2 in ...

The 49ers decide whether or not to play quarterback Brock Purdy, dealing with injury, for Week 13 against the Bills on Sunday ...

The 49ers' other inactives are defensive linemen Nick Bosa (hip, oblique) and Jordan Elliott (concussion), cornerback ...

The 49ers officially will have starting quarterback Brock Purdy for Sunday Night Football as he was not among their inactives ...