Buffalo has run consistently over the previously perceived vaunted 49ers defense to jump up to a halftime lead.

Buffalo Bills wide receiver Amari Cooper became the 62nd player in NFL history with 700 receptions in about the oddest way ...

Josh Allen’s latest kneel-down had nothing to do with football. The Buffalo Bills quarterback and actor Hailee Steinfeld posted a photo to their Instagram followers on Friday — 20.3 million for ...

The 49ers have been struggling for much of the season, but they had no shot in the snow on Sunday night in Western New ...

Post-Thanksgiving travel was treacherous in parts of the Great Lakes region Sunday due to several feet of lake-effect snow, ...

The 49ers' third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at ...

The San Francisco 49ers' losses to the Green Bay Packers and Buffalo Bills mark the worst two-game stretch by a defending ...

ORCHARD PARK, N.Y. (WROC) — In wintry conditions at Highmark Stadium, the Bills took down the 49ers 35-10 to win their fifth ...

San Francisco 49ers running back Christian McCaffrey suffered a knee injury and limped to the locker room in the second ...

San Francisco 49ers running back Christian McCaffrey suffered another injury in just his fourth game of the season. During ...

San Francisco 49ers running back Christian McCaffrey could be done for the season after just four games. As head coach Kyle ...

The 49ers just lost 35-10 to the Buffalo Bills. Now the 49ers are 5-7 and all alone in last place in the NFL West. Here are ...