San Francisco fumbled the ball three times and lost all three. Brock Purdy dropped back to pass 20 times for 86 net yards.

After sparking the 49ers with a handful of impressive runs, Christian McCaffrey looked like himself early in the game against ...

The Bills got the job done in their own snowy backyard against the 49ers in NFL Week 13 action. In a 35-10 final, the Bills ...

The Buffalo Bills proved snow can't stop them, which we've seen time and again in Western New York (hey, why are they ...

The Week 13 Sunday slate closes with the Buffalo Bills (9-2) hosting the San Francisco 49ers (5-6) on Sunday Night Football.

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” ...

The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...

Lake-effect snow has been hitting Buffalo throughout the holiday weekend with is expected to continue off and on through ...

A Buffalo Bills fan seemingly tried to use the snowy weather to their advantage on Sunday night as they appeared to toss a ...

The BetMGM bonus code is FPB50 for NFL betting and it offers an exclusive welcome bonus worth up to $1,550 for the Buffalo ...

The swagger is officially gone from this season's 49ers after another miserable outing in a 35-10 loss in Buffalo.

McCaffrey immediately checked himself out of the game and ran right into the medical tent. The 49ers star RB missed the ...