San Francisco 49ers vs Buffalo Bills showdown with essential stats, lineup predictions and injury updates you won’t want to ...

Running back Christian McCaffrey refuses to buy into the doom and gloom surrounding the San Francisco 49ers since two ...

Providing the betting odds and our preview and prediction for the star-studded matchup between the San Francisco 49ers and ...

Head coach Kyle Shanahan shared the final injury report on QB Brock Purdy, DL Nick Bosa and others and discussed the team's ...

One thing does not change, though. The defending NFC champion 49ers are 5-6 and they need to get on a heater - which will be ...

San Francisco 49ers running back Christian McCaffrey is in Buffalo for a Week 13 contest against the Bills on Sunday night.

Building winning Fantasy football picks requires a full understanding of Fantasy football injuries and Fantasy football ...

But even when most or all of those Niners took the field this year, closing out games has been a glaring weakness for a team expected to compete for the NFC. A loss to Seattle in Week 11 marked the ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night ...

There’s a running back renaissance taking place in the NFL and Christian McCaffrey has yet to take part in it.

Watch Matt Maiocco's full "Game Plan" interview with John Lynch at 9:30 p.m. PT Friday on NBC Sports Bay Area. SANTA CLARA — ...