According to head coach Kyle Shanahan, running back Christian McCaffrey suffered a potentially season-ending PCL injury in their 35–10 loss against the Buffalo Bills.

The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...

Finally, it's over. The San Francisco 49ers suffered an abysmal 35-10 loss to the Buffalo Bills. It wasn't a close game at all for the 49ers. Buffalo was in con ...

Christian McCaffrey's 2024/25 NFL season could be over in a devastating blow to the San Francisco 49ers after the 28-year-old ...

The swagger is officially gone from this season's 49ers after another miserable outing in a 35-10 loss in Buffalo.

The 49ers were among the preseason favorites to win the Super Bowl, but now they look like long shots to make the playoffs.

In a disappointing season a team typically reaches a point of no return, a realization that, “we have met the enemy, and it ...

The 49ers season is still trending down and now they're searching for answers on if they can get back on track.

The weather outside was frightful at Highmark Stadium in Orchard Park, New York on Sunday night, but the way the San ...

After Sunday night's humbling loss in snowy Buffalo, it's time for Kyle Shanahan and John Lynch to start shutting ...

The Buffalo Bills clinched another AFC East title with a dominant 35-10 win over the San Francisco 49ers; Josh Allen had ...