The temperature in the 49ers' loss to the Bills has something in common with their playoff chances -- it dropped rapidly.

The San Francisco 49ers' losses to the Green Bay Packers and Buffalo Bills mark the worst two-game stretch by a defending ...

Leading the way once again was the Bills’ quarterback, who was responsible for three of his team’s five touchdowns. ...

Somehow Week 13 was worse than for the San Francisco 49ers than Week 12. The 49ers fell behind 21-3 at halftime and had a ...

During Sunday Night Football against the Bills, Isaac Guerendo punched in his second touchdown of his rookie campaign.

Here is where the San Francisco 49ers sit in the NFL Week 14 power rankings after a loss to the Buffalo Bills on "Sunday ...

Snow flew like confetti in celebration from the packed stands as the Bills became the first team since 2009 to clinch a ...

Before the 2024 NFL season, Sunday night's Week 13 matchup between the Buffalo Bills and San Francisco 49ers might've been ...

The 49ers look to turn around their season with a win in Buffalo against the Bills, who are chasing the top seed in the AFC.

San Francisco 49ers running back Christian McCaffrey suffered another injury in just his fourth game of the season. During ...

The Bills controlled the game on the ground as the snow played a significant role, with Buffalo finishing the game with 220 ...

The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...