The 49ers just lost 35-10 to the Buffalo Bills. Now the 49ers are 5-7 and all alone in last place in the NFL West. Here are ...

The temperature in the 49ers' loss to the Bills has something in common with their playoff chances -- it dropped rapidly.

The San Francisco 49ers' losses to the Green Bay Packers and Buffalo Bills mark the worst two-game stretch by a defending ...

Here is where the San Francisco 49ers sit in the NFL Week 14 power rankings after a loss to the Buffalo Bills on "Sunday ...

Snow flew like confetti in celebration from the packed stands as the Bills became the first team since 2009 to clinch a ...

San Francisco 49ers running back Christian McCaffrey suffered another injury in just his fourth game of the season. During ...

The Bills controlled the game on the ground as the snow played a significant role, with Buffalo finishing the game with 220 ...

Josh Allen scored a receiving touchdown on a pass he threw in his latest do-everything performance, and the Buffalo Bills ...

ORCHARD PARK, N.Y. (WROC) — In wintry conditions at Highmark Stadium, the Bills took down the 49ers 35-10 to win their fifth ...

Buffalo Bills quarterback Josh Allen is now the franchise's sole leader in all-time total touchdowns. It’s long been obvious that quarterback Josh Allen would go down as one of, if not the, most ...

One week after a 38-10 road loss to the Green Bay Packers that stood out as one of their ugliest defeats in years, the San ...