The San Francisco 49ers' focus is right now entirely on their Week 13 matchup with the Buffalo Bills. However, there has already been a major change concerning their Week 14 game with the Chicago Bears.

The San Francisco 49ers, despite careening toward the abyss of NFL mediocrity, still have a path to the postseason as they enter their Week 13 showdown against the Buffalo Bills. Yet, thanks to the rest of the NFC West's tussle with the .

Under head coach Kyle Shanahan, the San Francisco 49ers have spent years falling just inches short of the franchise’s sixth Lombardi Trophy. The Niners have mad

San Francisco has been up and down all season, but the Super Bowl hangover appears to be happening after the 49ers got destroyed by the Green Bay Packers. Granted Brock Purdy didn't play, but the 49ers didn't look like an NFC contender.

San Francisco 49ers linebacker Fred Warner says he has been playing through a fractured bone in his ankle since Week 4. Warner suffered the injury

We thought San Francisco was poised for a massive second-half run after the Week 9 bye with Christian McCaffrey back, but the 49ers haven't looked good over their last three contests.  It wasn't a surprise the 49ers fell to the Green Bay Packers on Sunday with so many key contributors out.

With only a few weeks left on the college football slate, NFL draft season is beginning to hit its stride. Before the San Francisco 49ers meet the Buffalo Bills in Week 13, USA TODAY’s NFL Draft Wire released their latest predictions for the 2025 draft with a new mock draft.

Cold weather remains the Miami Dolphins' kryptonite, as their three-game winning streak came to an end on Thanksgiving night with a 30-17 loss to the

The Chicago Bears fired head coach Matt Eberflus following a catastrophic Thanksgiving Day 23-20 loss to the Detroit Lions. The Bears had a reputation of never firing a head coach midseason, but Eberflus somehow managed to change history.

The Buffalo Bills came soaring into their bye week during NFL Week 13 riding a six-game winning streak to a 9-2 record. They are preparing to host the 5-6 San Francisco 49ers for Sunday Night Football,